ABSTRACT
A vaccine is a material administered to an individual to boost their immune system's resistance against infection. Diseases that can be prevented by vaccination can be controlled and eradicated with proper vaccine handling and storage. It is crucial to formulate and deliver stable, effective and safe vaccines. Since vaccines are intricate biological products so any kind of temperature fluctuation can result in reduction of their effectiveness. To prevent this, cold storage facility is set up;refrigerators, thermometers and storage protocols are in place. The main vaccines distributed for COVID in India are Covishield and Covaxin. In order to maintain a cold chain supply for these vaccines, they must be transported and stored at a regulated temperature in accordance with the manufacturer's guidelines. The end-to-end supply chain for COVID-19 vaccines must adhere to specific cold chain standards from manufacturing to distribution in warehouses and healthcare facilities. Audits for cold chains and temperature monitoring should be performed regularly on the vaccine lots to ensure proper distribution practices are adhered. The present study focuses on the good distribution practice and storage of vaccines. Copyright © 2022 Wolters Kluwer Medknow Publications. All rights reserved.
ABSTRACT
Remdesivir is a prodrug that works by imitating the nucleoside adenosine. It is an antiviral medication that has been used to treat the coronavirus. Given the severity of the condition, the medicine is critical to the therapy and accompanying research. Remdesivir is extremely important as a medicinal dose form. Remdesivir has been used with other medications in the following combinations: Remdesivir and Dexamethasone, Remdesivir and Tocilizumab, and Remdesivir and Ivermectin. To aid future study, the paper also gives a simultaneous and comparative review of the analytical investigations published in the literature for a pharmacological estimate. The extensive literature searches turned up a plethora of study publications. A complete explanation of common, hyphenated, and unique ways of analysis is given. Remdesivir analytical quantification is provided using HPLC, LCMS, UV-Visible spectroscopy, and fluorescence. Copyright © 2022 Wolters Kluwer Medknow Publications. All rights reserved.